U.S. researchers have identified the specific pathway through which binge drinking contributes to clogged arteries, according to a new study.

U.S. researchers have identified the specific pathway through which binge drinking contributes to clogged arteries, according to a new study.

Binge drinking-related levels of acetaldehyde make immune cells called monocyctes more likely to stick to blood vessel walls and cause inflammation that contributes to blood vessel blockage — atherosclerosis, said the study published in the December issue of the journal Atherosclerosis.

The study, carried out by Medical Center of the University of Rochester, contributes to a growing body of evidence that drinking patterns have as much, or more, impact on cardiovascular disease risk than the total amount of alcohol consumed.

The findings may also help efforts to develop new treatments to counter atherosclerosis, which can lead to heart attack and stroke, the researchers said.

“Factors like binge drinking have been linked to increased risk for heart disease and the new inflammatory model is beginning to explain how,” said John Cullen, an assistant professor in the department of surgery who led the research.

“One of our experiments found that acetaldehyde, at levels found in the blood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 700 percent.”

Alcoholic beverages contain ethanol, which is mostly converted into acetaldehyde.

Binge drinking means having five or more drinks for men and four or more drinks for women in two hours, according to the U.S. National Institute on Alcohol Abuse and Alcoholism.

Some studies have suggested that an irregular pattern of heavy drinking increases the risk of heart attack about two-fold.

An estimated 65 percent of Americans drink alcohol with 15 percent reporting binge patterns, the researchers said.

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