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Study: Gene variant might lead to Schizophrenia

Published: 13/04/2009 05:00

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A gene variant may be linked with schizophrenia in some people, a discovery that will advance search for better treatments, a new study showed.

U.S. researchers spotted the gene variant while analyzing 24 Canadian families that had multiple members with schizophrenia, according to the study published in the April issue of the American Journal of Psychiatry.

A functional DNA change that increases gene expression was found in a gene called NOS1AP, said Linda Brzustowicz, a professor of genetics at Rutgers University in New Jersey, and his colleagues who conducted the study.

Previous researches have also found increased expression of NOS1AP in the brains of people with schizophrenia.

Identifying this altered gene is an important step in learning more about schizophrenia, but much more research into other causes is required, Brzustowicz said.

She noted that schizophrenia is not a single-gene disorder and there are environmental factors that are also important.

“It’s not as though, if you have this altered gene, you will get the disease,” she said in a Rutgers news release.

More than 40 percent of people in the general population have the gene variant, but only 1 percent have schizophrenia, and not all of those with the illness have the altered gene, Brzustowicz said.

But she added that the frequency of the altered gene is higher among people with schizophrenia than in the general population. For example, 55 percent of the schizophrenia patients in this study had the gene variant.

VietNamNet/Xinhuanet

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