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Study: Gene predicts response to standard treatment

Published: 16/08/2009 05:00

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A tiny variation in a person’s genetic code could explain why some racial and ethnic groups fare more poorly on standard treatments than others, according to news reports on Monday.

The gene variant is more common in people with European ancestry than African-Americans, researchers said.

“This discovery enables us to give patients valuable information that will help them and their doctors decide what is best for them,” genetics researcher David Goldstein of Duke University in Durham, North Carolina, said in a statement on Sunday.

The work involved 1,137 patients who had a chronic infection with the most common type of hepatitis C virus found in the United States and Europe, one that is less responsive to treatment than other types. They were given standard drug treatment.

Analysis showed the treatment wiped out the virus in about 80 percent of study participants with the favorable genetic variant, compared to only about 30 percent among those who lacked it.

Hepatitis C is a blood-borne liver disease that can lead to chronic liver problems, liver cancer, cirrhosis and death. The virus affects an estimated 3.2 million people in the United States alone and 170 million worldwide.

VietNamNet/Xinhuanet

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