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Vitamin D deficiency linked with cardiovascular disease, death

Published: 17/11/2009 05:00

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People with inadequate levels of vitamin D may face greater risk of stroke, heart disease, and death, even though they’ve never had heart disease.

Researchers at the Heart Institute at Intermountain Medical Center in Salt Lake City presented their findings to the American Heart Association’s Scientific Conference which opened on Monday in Orlando, Florida.

The more-than-one-year study involved 27,686 patients who were 50 years of age or older with no prior history of cardiovascular disease. The participants had their blood Vitamin D levels tested during routine clinical care. The patients were divided into three groups based on their Vitamin D levels — normal (over 30 nanograms per milliliter), low (15-30 ng/ml), or very low (less than 15 ng/ml). The patients were then followed to see if they developed some form of heart disease.

The study found that patients with very low levels of Vitamin Dwere 77 percent more likely to die, 45 percent more likely to develop coronary artery disease, and 78 percent were more likely to have a stroke than patients with normal levels. Patients with very low levels of Vitamin D were also twice as likely to develop heart failure than those with normal Vitamin D levels.

Previous studies had linked vitamin D deficiency to musculoskeletal disorders, and to the regulation of many other bodily functions including blood pressure, glucose control, and inflammation, all of which are important risk factors related to heart disease. From these results, scientists have postulated that Vitamin D deficiency may also be associated with heart disease itself.

“This was a unique study because the association between Vitamin D deficiency and cardiovascular disease has not been well-established,” said Brent Muhlestein, MD, director of cardiovascular research of the Heart Institute at Intermountain Medical Center and one of the authors of the new study.

“Its conclusions about how we can prevent disease and provide treatment may ultimately help us save more lives.”

But Muhlestein said that as the study was only observational, definitive links between Vitamin D deficiency and heart disease could not be assigned — but the findings create an impetus for further study.

VietNamNet/Xinhuanet

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